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Abstract: Human red blood cells (RBCs) exhibit spontaneous vibratory motions, referred to as flickering. As a RBC ages, the rigidity of the membrane increases, affecting the cell?s oxygen-carrying and delivery capacity. Detecting aged cells has important medical applications. Previous work using measurements of the cell roughness has indicated that older or diseased cells show significantly less roughness and temporal complexity than newly-formed and healthy cells. 

Computational Topology is a relatively young field, and has proven succeeded in many scientific fields. In our work, we use persistent homology, a tool in computational topology, to study RBCs, and discover that topologically, these two types cells are different.

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Junping Shi

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