Chemistry Events
Physics Colloquium - Dr. Joseph Reiner
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- Open to the public
Title: Nanoparticle-enhanced nanopore detection of ovarian cancer-marking peptides
Abstract: Nanopore sensing provides numerous advantages for single molecule detection. Early efforts focused on the development of DNA sequencing, but more recent work has focused on protein and peptide detection. My lab is exploring the use of cluster-modified nanopore detection to isolate and analyze water soluble peptides up to 2 kDa. Our goal is to develop a single molecule sensor capable of detecting cancer-marking peptides for early onset diagnosis. This talk will provide a background on cluster-modified nanopore detection, its application towards peptide sensing, detection of ovarian cancer marker peptides in urine and preliminary results related to the detection of phosphorylated peptides. Work supported by NSF-CBET 2011173.
Speaker biographical sketch: Joseph Reiner’s research career started at SUNY Stony Brook in 1997 working on experimental quantum optics under the guidance of Prof. Luis Orozco. He graduated in 2003 and received a National Research Council Postdoctoral Fellowship at the National Institute of Standards and Technology (NIST) working in the optical trapping group of William D. Phillips (Nobel Laureate 1997). During this time he developed an interest in single molecule biophysics and nanopore sensing. He left NIST in 2011 and joined the Physics Department at the Virginia Commonwealth University, in Richmond, VA where he is the PI of a research group that focuses on nanopore sensing. He was promoted to Full Professor in the spring of 2023, and he is currently serving as Chairman of the Physics Department.
Sponsored by: Physics